MSC/Circ.848 and MSC.1/Circ.1267 permit halocarbon agents
to be used in concentrations up to the No Observed Adverse Effect
Level (NOAEL) calculated on the net volume of the protected space
at the maximum expected ambient temperature without additional safety
measures. In no case should halocarbon agents be used at concentrations
above the Lowest Observed Adverse Effect Level (LOAEL). These Guidelines
prescribe the recommended protocol for determining the referred-to
NOAEL and LOAEL levels.