5.1.1 An assessment on the intrinsic properties
of the Active Substance and/or Preparation such as persistency, bioaccumulation
and toxicity should be conducted (see Table 1 in section 6).
-
.1 Persistence tests:
Persistence should preferably be assessed in simulation test
systems that determine the half-life under relevant conditions. Biodegradation
screening tests may be used to show that the substances are readily
biodegradable. The determination of the half-life should include assessment
of relevant chemicals.
-
.2 Bioaccumulation tests:
The assessment of the (potential for) bioaccumulation should
use measured bioconcentration factors in marine (or freshwater) organisms.
Where these tests are not applicable, or if logPow <3, Bio Concentration
Factor (BCF) values may be estimated using (Quantitative) Structure-Activity
Relationship ((Q)SAR) models.
-
.3 Toxicity tests:
Acute and/or chronic ecotoxicity data, ideally covering the
sensitive life stages, should in principle be used for the assessment
of the toxicity criterion.